University of Colorado Denver

INSTRUCTIONS FOR CLOMIPHENE CITRATE CHALLENGE TEST (CCCT) AND ANTI-MULLERIAN HORMONE (AMH)

The Clomiphene Citrate Challenge Test (CCCT) assesses how likely it is that a woman will conceive using assisted reproduction. About 10% of women who are infertile will have an abnormal CCCT. The incidence of an abnormal result increases with age. In one research study using the CCCT, conception only occurred in only 9% of patients with an abnormal CCCT result. This compares to a conception rate of 43% in patients with a normal CCCT result in the same study. (Obstetrics and Gynecology 1993; 82:539-444). In addition you will have an anti-mullerian hormone (AMH) level drawn which has recently also been shown to predict pregnancy potential.

Directions for Doing the Test

  • You will come for blood work on cycle day 3. At this time you will have a blood test for FSH, AMH, and estradiol. Please call to schedule this blood work (720-848-1690).
  • You then take the medicine clomiphene citrate (Serophene, Clomid) for 5 days. You should take 2 tables (100 mg) each day, on days 5 through 9 of your cycle.
  • You return on cycle day 10 (the day after the last day of clomiphene pills) for a repeat blood test for FSH and estradiol. Again, please call to schedule these blood tests (720-848-1690, option 1).
Interpretation Of Results:
The CCCT is considered abnormal if:

  • Either on day 3 or day 10 FSH was >10 mIU/mL
  • If the day 3 estradiol was >75 pg/mL
  • An AMH < 1.0 ng/ml is considered abnormal

Your doctor will interpret and discuss your results with you. There are many factors that can affect the results.

University of Colorado Denver
Advanced Reproductive Medicine

Anschutz Medical Campus Office
Location: 1635 Aurora Court, Aurora, CO 80045
Mailing: PO Box 6510, Mail Stop F701, Aurora, CO 80045
Tel: 720.848.1690
Toll-free: 1.888.899.7441
Fax: 720.848.1678
Colorado Springs Office
4125 Briargate Parkway, Suite 350
Colorado Springs, CO 80920
Tel: 719.314.3333
Fax: 719.314.3344

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