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How and where to order Clomid (Clomifene Citrate) 25 mg, 50 mg, 100 mg tablets or capsules online on Colorado Infertility Doctors:
Shop: | DFH PHARMACY
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Prices: | from $0.37 per pill
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Discount: | 10% coupon: DFHDCC
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Forms: | 25 mg, 50 mg, 100 mg tablets
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Quantity: | 30-360 pills
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Type: | Clomiphene brand, Fertomid brand, Clomid generic, Serophene generic
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Clomiphene Citrate (USAN) or Clomifene Citrate (INN) (trade names include Clomid, Fertomid, Serophene, Clofert, Clomhexal, Clomifen, Clomifene, Clomifeno, Clostilbegyt, Fertyl, Ikaclomin, Omifin, Ova-Mit, Ovinum, Ovofar, Ovulet, Pergotime, Prolifen, Siphene) is a well-known and commonly prescribed fertility medication from synthetic ovulation stimulants pharmacological group. This medicine is used to increase the chance of getting pregnant, for treating female infertility (ovulatory dysfunction) by helping women ovulate (produce a mature egg) properly during their cycle. Sometimes clomiphene is prescribed to men with fertility problems due to low sperm counts.
Related medications:
Bromocriptine (Parlodel)
Butylscopolamine (Buscopan)
Cabergoline (Dostinex)
Clotrimazole (Gyne-Lotrimin)
Cyclofenil (Fertodur)
Danazol (Danocrine)
Dydrogesterone (Duphaston)
Eflornithine (Vaniqa)
Epimestrol (Stimovul)
Estradiol (Estrace)
Estrogens conjugated (Premarin)
Exemestane (Aromasin)
Ibandronate (Boniva)
Medroxyprogesterone (Cycrin)
Norethindrone (Norlutate)
Norethisterone (Aygestin)
Progesterone (Prometrium)
Raloxifene (Evista)
Tamoxifen (Nolvadex)
Pharmacological and medical categories:
Estrogen agonist-antagonists
Ovulation stimulation drugs
Trophic hormones and related synthetic drugs
Medications for the treatment of female infertility
Men's health
Women's health
ATC codes:
G - Genito urinary system and sex hormones
G03 - Sex hormones and modulators of the genital system
G03G - Gonadotropins and other ovulation stimulants
G03GB - Ovulation stimulants, synthetic
G03GB02 - Clomifene
ICD-10 codes:
Ovarian dysfunction - E28
Male infertility - N46
Other disorders of breast - N64
Absent, scanty and rare menstruation - N91
Female infertility - N97
Indications and usage:
Clomid (Clomiphene Citrate) tablets are indicated for the treatment of ovulatory dysfunction in women desiring pregnancy. Impediments to achieving pregnancy must be excluded or adequately treated before beginning Clomid therapy. Those patients most likely to achieve success with clomiphene therapy include patients with polycystic ovary syndrome, amenorrhea-galactorrhea syndrome, psychogenic amenorrhea, post-oral-contraceptive amenorrhea, and certain cases of secondary amenorrhea of undetermined etiology.
Properly timed coitus in relationship to ovulation is important. A basal body temperature graph or other appropriate tests may help the patient and her physician determine if ovulation occurred. Once ovulation has been established, each course of Clomiphene (Clomid) should be started on or about the 5th day of the cycle. Long-term cyclic therapy is not recommended beyond a total of about six cycles (including three ovulatory cycles).
Clomid tablets are indicated only in patients with demonstrated ovulatory dysfunction who meet the conditions described below:
Patients who are not pregnant.
Patients without ovarian cysts. Clomiphene Citrate (Clomid) should not be used in patients with ovarian enlargement except those with polycystic ovary syndrome. Pelvic examination is necessary prior to the first and each subsequent course of Clomid treatment.
Patients without abnormal vaginal bleeding. If abnormal vaginal bleeding is present, the patient should be carefully evaluated to ensure that neoplastic lesions are not present.
Patients with normal liver function.
In addition, patients selected for Clomid therapy should be evaluated in regard to the following:
Estrogen Levels. Patients should have adequate levels of endogenous estrogen (as estimated from vaginal smears, endometrial biopsy, assay of urinary estrogen, or from bleeding in response to progesterone). Reduced estrogen levels, while less favorable, do not preclude successful therapy.
Primary Pituitary or Ovarian Failure. Clomiphene therapy cannot be expected to substitute for specific treatment of other causes of ovulatory failure.
Endometriosis and Endometrial Carcinoma. The incidence of endometriosis and endometrial carcinoma increases with age as does the incidence of ovulatory disorders. Endometrial biopsy should always be performed prior to Clomid therapy in this population.
Other Impediments to Pregnancy. Impediments to pregnancy can include thyroid disorders, adrenal disorders, hyperprolactinemia, and male factor infertility.
Uterine Fibroids. Caution should be exercised when using Clomiphene in patients with uterine fibroids due to the potential for further enlargement of the fibroids.
There are no adequate or well-controlled studies that demonstrate the effectiveness of Clomid pills in the treatment of male infertility. In addition, testicular tumors and gynecomastia have been reported in males using clomiphene. The cause and effect relationship between reports of testicular tumors and the administration of Clomid is not known.
Although the medical literature suggests various methods, there is no universally accepted standard regimen for combined therapy (ie, Clomid in conjunction with other ovulation-inducing drugs). Similarly, there is no standard Clomiphene tablets regimen for ovulation induction in in vitro fertilization programs to produce ova for fertilization and reintroduction. Therefore, Clomid tablets are not recommended for these uses.
Dosage and administration:
General Considerations
The workup and treatment of candidates for Clomid (Clomiphene Citrate) tablets therapy should be supervised by physicians experienced in management of gynecologic or endocrine disorders. Patients should be chosen for therapy with Clomid only after careful diagnostic evaluation. The plan of therapy should be outlined in advance. Impediments to achieving the goal of therapy must be excluded or adequately treated before beginning Clomid. The therapeutic objective should be balanced with potential risks and discussed with the patient and others involved in the achievement of a pregnancy.
Ovulation most often occurs from 5 to 10 days after a course of Clomid. Coitus should be timed to coincide with the expected time of ovulation. Appropriate tests to determine ovulation may be useful during this time.
Recommended Dosage
Treatment of the selected patient should begin with a low dose, 50 mg daily (1 tablet) for 5 days. The dose should be increased only in those patients who do not ovulate in response to cyclic 50 mg Clomid. A low dosage or duration of treatment course is particularly recommended if unusual sensitivity to pituitary gonadotropin is suspected, such as in patients with polycystic ovary syndrome.
The patient should be evaluated carefully to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between each treatment cycle.
If progestin-induced bleeding is planned, or if spontaneous uterine bleeding occurs prior to therapy, the regimen of 50 mg daily for 5 days should be started on or about the 5th day of the cycle. Therapy may be started at any time in the patient who has had no recent uterine bleeding. When ovulation occurs at this dosage, there is no advantage to increasing the dose in subsequent cycles of treatment.
If ovulation does not appear to occur after the first course of therapy, a second course of 100 mg daily (two 50 mg tablets given as a single daily dose) for 5 days should be given. This course may be started as early as 30 days after the previous one after precautions are taken to exclude the presence of pregnancy. Increasing the dosage or duration of therapy beyond 100 mg/day for 5 days is not recommended.
The majority of patients who are going to ovulate will do so after the first course of therapy. If ovulation does not occur after three courses of therapy, further treatment with Clomid is not recommended and the patient should be reevaluated. If three ovulatory responses occur, but pregnancy has not been achieved, further treatment is not recommended. If menses does not occur after an ovulatory response, the patient should be reevaluated. Long-term cyclic therapy is not recommended beyond a total of about six cycles.
Overdosage:
Signs and symptoms
Toxic effects accompanying acute overdosage of clomiphene have not been reported. Signs and symptoms of overdosage as a result of the use of more than the recommended dose during CLOMID therapy include nausea, vomiting, vasomotor flushes, visual blurring, spots or flashes, scotomata, ovarian enlargement with pelvic or abdominal pain.
Oral LD50: The acute oral LD50 of clomiphene is 1700 mg/kg in mice and 5750 mg/kg in rats. The toxic dose in humans is not known.
Dialysis: It is not known if clomiphene is dialyzable.
Treatment
In the event of overdose, appropriate supportive measures should be employed in addition to gastrointestinal decontamination.
Contraindications:
Hypersensitivity. Clomid is contraindicated in patients with a known hypersensitivity or allergy to clomiphene citrate or to any of its ingredients.
Pregnancy. Pregnancy Category X. Clomid pills use in pregnant women is contraindicated, as Clomiphene does not offer benefit in this population.
Available human data do not suggest an increased risk for congenital anomalies above the background population risk when used as indicated. However, animal reproductive toxicology studies showed increased embryo-fetal loss and structural malformations in offspring. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential risks to the fetus.
Liver Disease. Clomid therapy is contraindicated in patients with liver disease or a history of liver dysfunction.
Abnormal Uterine Bleeding. Clomiphene is contraindicated in patients with abnormal uterine bleeding of undetermined origin.
Ovarian Cysts. Clomid is contraindicated in patients with ovarian cysts or enlargement not due to polycystic ovarian syndrome
Clomid is contraindicated in patients with uncontrolled thyroid or adrenal dysfunction or in the presence of an organic intracranial lesion such as pituitary tumor.
Adverse reactions, side effects:
Clomid tablets, at recommended dosages, is generally well tolerated. Side effects usually have been mild and transient and most have disappeared promptly after treatment has been discontinued. Adverse experiences reported in patients treated with clomiphene citrate are following:
Abdominal-pelvic discomfort/distention/bloating
Abnormal uterine bleeding
Breast discomfort
Headache
Nausea and vomiting
Ovarian enlargement
Vasomotor flushes
Visual symptoms
Drug Interactions:
Drug interactions with clomiphene have not been documented.
Pregnancy categories:
B3 - Australia
X - United States (Should not be used during pregnancy)
Salts and other forms:
Clomiphene Base
Clomiphene Citrate
Synonyms, international and chemical names:
Chlomaphene
Chloramiphene
Cis-Clomifene
Cisclomifenum
Cisclomiphene
Cis-Clomiphene
Clomifeen
Clomifen
Clomifene
Clomifeno
Clomifenum
Clomiphen
Clomiphene B
Clomiphenum
Klomifen
Zuclomifene
Zuclomifeno
Zuclomifenum
Zuclomiphene
Brands, generics, trade names:
Clofert - Svizera Healthcare
Clomhexal - Hexal, DKSH, Hexanel, Sandoz
Clomid - Sanofi-Aventis
Clomifen - Leiras
Clomifene - Wockhardt
Clomifeno - Casen Fleet
Clomihexal - Hexal, Sandoz
Clomiphen - Arcana Arzneimittel
Clomiphene - Par Pharmaceutical, Y.S.P. Industries
Clostil - Egis, PharmAsia-Cuvest
Clostilbegyt - Egis
Duinum - Medochemie, Derek Marketing, Komedic, Medline, Thailand, Star Medical Supplies
Fertilan - Codal Synto, CNW Hong Kong, Hong Tai Hong, Star Medical Supplies
Fertomid - Cipla
Fertyl - Renata, Ar-Ex Laboratories, Euro Generics, Metro Pharma Philippines
Genozym - Bristol-Myers Squibb
Ikaclomin - Teva
Omifin - Sanofi-Aventis, Effik
Ovagen - Walter Bushnell
Ovamit - Remedica, Pharmadica
Ova-Mit - Ebewe Pharma
Ovinum - Biolab, Biopharm Chemicals, Indrugco, Medispec
Ovofar - Organon
Ovulet - Renata, Beracah Pharma Phils, Euro Generics
Ovulin - Euro Generics, Marzan Pharma Corporation
Pergotime - Serono, Merck
Profertil - Kalbe Farma, Apotheca Marketing, Mega Lifesciences
Prolifen - Effik
Provula - Dexa Medica Pharm & Chem
Rejun - Uni Sankyo
Serofene - Serono, Novartis
Serophene - Serono, Allphar Services, Douglas Pharmaceuticals, Merck, Pharmascience
Serpafar - Faran Laboratories
Siphene - Serum Institute of India
Siphene-M - Serum Institute of India
Zimaquin - Recalcine Laboratorios
APIs used in medicine in combinations with clomiphene:
Astaxanthin
Folic Acid
L-Carnitine
L-Arginine
Lycopene
Methylcobalamin
N-Acetylcysteine
Ubidecarenone
Here is a list of popular medications containing clomiphene as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
Trade name of the drug |
Pharmaceutical forms and doses |
Companies |
Clomid |
Tablets; Oral; Clomiphene Citrate 50 mg |
Sanofi-AventisDKSH |
Clostilbegyt |
Tablets; Oral; Clomiphene Citrate 50 mg |
EgisDelfi SingaporeMedphano ArzneimittelMekimPahang PharmacySime Darby Marketing |
Fertomid |
Tablets; Oral; Clomiphene Citrate 25 mgTablets; Oral; Clomiphene Citrate 50 mgTablets; Oral; Clomiphene Citrate 100 mg |
Cipla |
Ova-Mit |
Tablets; Oral; Clomiphene Citrate 50 mg |
Ebewe PharmaCorbridge GroupGoldplus UniversalIDS GroupJDH PharmaceuticalPharmadicaPrimal ChemicalRemedica |
Ovofar |
Tablets; Oral; Clomiphene Citrate 50 mg |
OrganonInfar India |
Serophene |
Tablets; Oral; Clomiphene Citrate 50 mg |
SeronoAllphar ServicesAntah PharmaApex Pharma MarketingDKSHDouglas PharmaceuticalsFour StarMerckPharmascience |
References:
Clomiphene main article on Wikipedia: https://en.wikipedia.org/wiki/Clomiphene
Clomiphene compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Clomifene
Clomiphene Citrate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Clomiphene-citrate
Clomiphene medicine on DrugBank: https://www.drugbank.ca/drugs/DB00882
Clomiphene Citrate on DrugBank: https://www.drugbank.ca/salts/DBSALT000490
Clomiphene FAQ on MedlinePlus (revised 09/15/2017): https://medlineplus.gov/druginfo/meds/a682704.html
Clomiphene Citrate tablets drug label info on DailyMed (revised August 29, 2019): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Clomiphene containing drugs on Drugs-About.com: https://drugs-about.com/ing/clomiphene.html
Clomiphene for sale on Pharma Doctor: https://pharma-doctor.com/clomiphene.html
Clomiphene international drug names on Drugs.com: https://www.drugs.com/international/clomifene.html
Clomid (Clomiphene Citrate) 50 mg tablets official prescribing information from the U.S. FDA (revised October 2012): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Clomid (Clomiphene Citrate) 50 mg tablets product monograph and consumer information from Sanofi-Aventis pharmaceutical company (revised August 9, 2013): https://products.sanofi.ca/en/clomid.pdf
Serophene (Clomiphene Citrate) 50 mg tablets product information from GP2U TeleHealth (revised 8 February 2008): https://gp2u.com.au/static/pdf/S/SEROPHENE-PI.pdf
Clomid (Clomiphene Citrate) 50 mg tablets patient information leaflet on Medicines.org.uk (revised December 2019): https://www.medicines.org.uk/emc/files/pil.961.pdf
Fertomid (Clomiphene Citrate) 25 mg, 50 mg, 100 mg tablets for oral use on Cipla pharmaceutical company website (revised 05 November 2020): https://www.ciplamed.com/content/fertomid-tablets
Revised: April 2021
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