The Clomiphene Citrate Challenge Test (CCCT) assesses how likely it is that a woman will conceive using assisted reproduction. About 10% of women who are infertile will have an abnormal CCCT. The incidence of an abnormal result increases with age. In one research study using the CCCT, conception only occurred in only 9% of patients with an abnormal CCCT result. This compares to a conception rate of 43% in patients with a normal CCCT result in the same study. (Obstetrics and Gynecology 1993; 82:539-444). In addition you will have an anti-mullerian hormone (AMH) level drawn which has recently also been shown to predict pregnancy potential.

Directions for Doing the Test

• You will come for blood work on cycle day 3. At this time you will have a blood test for FSH, AMH, and estradiol. Please call to schedule this blood work (720-848-1690).
• You then take the medicine clomiphene citrate (Serophene, Clomid) for 5 days. You should take two 50 mg tablets (100 mg) each day, on days 5 through 9 of your cycle.
• You return on cycle day 10 (the day after the last day of clomiphene pills) for a repeat blood test for FSH and estradiol. Again, please call to schedule these blood tests (720-848-1690, option 1).

• Either on day 3 or day 10 FSH was >10 mIU/mL
• If the day 3 estradiol was >75 pg/mL
• An AMH < 1.0 ng/ml is considered abnormal

Your doctor will interpret and discuss your results with you. There are many factors that can affect the results.

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